EFFICACY AND SAFETY OF RADOTINIB IN CHRONIC PHASE CHRONIC MYELOID LEUKEMIA PATIENTS WITH RESISTANCE OR INTOLERANCE TO BCR-ABL1 TYROSINE KINASE INHIBITORS

Radotinib (IY5511HCL), a novel and selective BCR-ABL1 tyrosine kinase inhibitor, has shown pre-clinical and phase I activity and safety in chronic myeloid leukemia.This phase II study investigated the efficacy and safety of radotinib in Philadelphia chromosome-positive chronic phase-chronic myeloid leukemia 888392593481 patients with resistance and

This paper presents the results of the mineralogical and petrographic analysis of non-classical wheel-thrown grey ware of the early 1st millennium AD from Tanais and Alanian settlements of Central Ciscaucasia.The examined 28 samples were divided into three series.The control series includes fragments of coarse-clay vessels of the most typical early

Artificial fire is the main cause of forest fires, and human intervention can reduce the occurrence of forest fires.Yunnan province is a province with a high incidence of forest fires.A large number of flammable shrubbery are distributed in many regions.The study on the time scale and space weboost splitter scale of shrubbery fires caused by human

Malaria continues to wreak katin harold jacket havoc in the Peruvian Amazon.Lengthy research efforts have brought important lessons on its particular epidemiology: the heterogeneous levels of transmission, the large reservoir of both asymptomatic and submicroscopic infections, the co-transmission of Plasmodium vivax and Plasmodium falciparum in the

Designing nonlinear optimal controllers such as Minimum Variance Controller (MVC) has many difficulties.Main difficulties are 1) in order to design controller; the explicit relations between outputs and inputs must be executable.This relation is defined implicitly in the katin harold jacket nonlinear models; 2) learning controller is high dimension